• The exact cause is not known. Hereditary and environmental factors may play a role in developing the disease.
• The risk factors include:
• Mutations in the DNA are frequently a major cause.
• Sometimes chromosome translocation can also promote activation of oncogenes (the cancer inducing genes) and this can lead to disease progression.
• Exposure to certain chemicals and radiation can also induce cancer.

Complications include:

• Weight Loss
• Anemia
• Tumor lysis syndrome
• Transformation of chronic lymphoma to aggressive one called Richter transformation.
• Chances of developing autoimmune disorders.
• Development of secondary cancer.
• Infertility
• Slow growth
• Damage of central nervous system.
• Cataract
• Side effects of chemotherapy drugs.